1936–1966
Alkaloid’s First Steps
The period from 1946 to 1956 marked Alkaloid’s first steps towards increasing production, modernizing technology, expanding its manufacturing activities, and improving the qualification structure of its employees. The year 1957 was particularly significant for Alkaloid’s development, when a new facility for the production of medicinal products, the Galenic Production Facility, was commissioned. Another important chapter in Alkaloid’s development was the beginning of business and technical cooperation with renowned global pharmaceutical and chemical corporations.
1936
The quality of Macedonian poppy was instrumental in the establishment of Alkaloid
1950
On August 29, 1950, the so-called workers’ self-management system was introduced at the factory
1957
The Galenic Production Facility was commissioned, and Caffetin production began
1961
Cooperation with renowned global pharmaceutical and chemical corporations
1966–1994
Building a Modern Pharmaceutical Infrastructure
In 1966, the Research and Development Institute was commissioned as a dedicated segment of Alkaloid, established to support the company’s overall development and technology program. The vision of creating a modern pharmaceutical company began to take shape in 1972 with the opening of a new finished medicinal products factory. In 1979, the Medicinal Plant Processing Factory was commissioned.
1966
The Research and Development Institute was commissioned
1972
New finished medicinal products factory
1973
Integration with the Factory for Production of Chemicals and Photomaterials, Lafoma, and the Soap and Cosmetics Factory, Cvetan Dimov
1975
Alkaloid’s new Administrative Building was commissioned
1978
The Factory for Paints and Varnishes, Proleter, was integrated into Alkaloid
1979
Launch of the Medicinal Plant Processing Factory
1994–2006
Strategic Development and International Recognition
Signing of the Convertible Loan Agreement between J. Wolfensohn of the World Bank (EBRD/IFC) and T. Mukaetov of Alkaloid in 1999. The new facility for solid pharmaceutical dosage forms, built in accordance with strict Good Manufacturing Practice (GMP) standards, was commissioned in 2000. In November 2002, the company was listed on the official market of the Macedonian Stock Exchange.
1998
Alkaloid was registered as a privately owned joint-stock company
1999
Signing of the Convertible Loan Agreement with the EBRD and IFC
2000
New facility for solid pharmaceutical dosage forms and construction of facilities for the production of semi-synthetic cephalosporins
November 2002
Alkaloid was listed on the official market of the Macedonian Stock Exchange
2007–2026
Investments That Shaped the Modern Alkaloid
Key milestones in Alkaloid’s development from 2007 to the present.
2007
Trajche Mukaetov Foundation established to support talented medical and pharmacy students
2007
IT segment; implementation of SAP/ERP, DMS, CRM, etc.
2009
New Research and Development Institute
2010
New production facility in Belgrade, Republic of Serbia
2010
New Trajche Mukaetov Information Technology Centre
2013
New high-bay warehouse in Gjorche Petrov
2015
New Quality Control Centre
2017
Production facility for semi-solid pharmaceutical forms, central weighing room 2 and packaging unit
2019
Reconstruction and expansion of pharmaceutical manufacturing facilities
2020
New production department for wet wipes
2021
New Training and Education Centre
2021
New production facility for dialysis concentrates
2022
New warehouse for pharmaceutical raw materials and primary packaging materials
2022
New equipment for the cosmetics manufacturing laboratory
2024
Tablet 2.0 production facility for solid dosage forms
2025
Opening of a new Microbiology Laboratory for Quality Control
